Friday, March 21, 2014

Innovative technique to deliver curcumin to combat cancer

Innovative technique to deliver curcumin to combat cancer
A team of scientists from Nizam's Institute of Medical Sciences led by Dr. Vijay Kumar Kutala, Associate Professor, Dept of Clinical Pharmacology, in collaboration with Dr. Srigiridhar Kotamraju, Senior Scientist from Indian Institute of Chemical Technology, Hyderabad, discovered an innovative technique to deliver curcumin into mitochondria by tagging it with a chemical moiety called, "triphenylphosphonium ion."

Turmeric which is part of our household for centuries has an active ingredient Curcumin, inherent with several medicinal properties. Curcumin’s efficiency in cancer prevention is well documented by several research studies. However, its use in clinics is limited due to its inability to penetrate the cells. This novel process developed by the NIMS and IICT teams enhances intracellular uptake of curcumin many hundred folds and is effective in killing the cancer cells without harming the normal cells. This research finding was published in the current issue of the highly reputed scientific journal "PLOS One" and was appreciated by the scientific community.

According to Dr. Vijay Kumar Kutala, ‘this is a major breakthrough in the treatment of cancers especially breast cancer, prostate cancer, cervical cancer and neuroblastoma cancers. This pioneering step in increasing the efficiency of herbal medicine through modern technology and delivery mechanism will immensely benefit mankind.